Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods

Autor/inn/en	Burian, Alexis N.; Zhao, Wufan; Lo, Te-Wen; Thurtle-Schmidt, Deborah M.
Titel	Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods
Quelle	In: Biochemistry and Molecular Biology Education, 49 (2021) 5, S.815-825 (11 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Lo, Te-Wen) ORCID (Thurtle-Schmidt, Deborah M.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1470-8175
DOI	10.1002/bmb.21561
Schlagwörter	Leitfaden; Unterricht; Lehrer; Genetics; Science Instruction; Teaching Methods; Biology; Statistical Analysis; Medicine; Data Analysis; Ethics; Social Problems; Scientific Research; Case Studies; Guides + Suchen Sie Ihr Suchwort? Lesson concept; Instruction; Unterrichtsentwurf; Unterrichtsprozess; Teacher; Teachers; Lehrerin; Lehrende; Humangenetik; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Teaching method; Lehrmethode; Unterrichtsmethode; Biologie; Statistische Analyse; Medizin; Auswertung; Ethik; Social problem; Soziales Problem; Case study; Fallstudie; Case Study; Handbuch; Leitfaden
Abstract	To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called "-omics," have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated, including anticipatory guides and discussion questions for active engagement in the classroom. Additionally, the Supporting Information includes a case study to apply technical and ethical concepts from the text. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01