Practicing Logical Reasoning through "Drosophila" Segmentation Gene Mutants

Autor/inn/en	Bargiela, Ariadna; Artero, Ruben
Titel	Practicing Logical Reasoning through "Drosophila" Segmentation Gene Mutants
Quelle	In: Biochemistry and Molecular Biology Education, 49 (2021) 5, S.729-736 (8 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Bargiela, Ariadna) ORCID (Artero, Ruben)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1470-8175
DOI	10.1002/bmb.21554
Schlagwörter	Animals; Logical Thinking; Genetics; Science Instruction; Laboratory Experiments; Biology; Teaching Methods; Classification; Anatomy; Thinking Skills + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Humangenetik; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Laboratory work; Laborarbeit; Biologie; Teaching method; Lehrmethode; Unterrichtsmethode; Classification system; Klassifikation; Klassifikationssystem; Anatomie; Denkfähigkeit
Abstract	Laboratory practical sessions are critical to scientific training in biology but usually fail to promote logical and hypothesis-driven reasoning and rely heavily on the teacher's instructions. This paper describes a 2-day laboratory practicum in which students prepare and analyze larval cuticle preparations of "Drosophila" segmentation gene mutant strains. Embryonic segmentation involves three major classes of genes according to their loss-of-function phenotypes: the establishment of broad regions by gap genes, the specification of the segments by the pair-rule genes, and the compartments within segments by the segment polarity genes. Students are asked to sort undefined segmentation mutants into gap, pair-rule, or segment polarity categories based on their knowledge of the "Drosophila" segmentation process and the microscopic anatomical traits they are capable of finding in the sample preparations. This technically simple practicum prompts students to pay attention to detailed observation to detect anatomic markers of intrasegmental compartments and thorax versus abdomen cuticle, and promote their logical reasoning in hypothesizing to which segmentation type a given mutant fits best. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01