Short-Term Memory Reactivation of a Weak CS-US Association Promotes Long-Term Memory Persistence in Conditioned Odor Aversion

Autor/inn/en	Tovar-Díaz, Jorge; Morín, Jean-Pascal; Ríos-Carrillo, Jorge Eduardo; de Jesús, Hilda Sánchez; Roldán-Roldán, Gabriel
Titel	Short-Term Memory Reactivation of a Weak CS-US Association Promotes Long-Term Memory Persistence in Conditioned Odor Aversion
Quelle	In: Learning & Memory, 28 (2021) 5, S.153-161 (9 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Tovar-Díaz, Jorge) ORCID (Morín, Jean-Pascal)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.053385.120
Schlagwörter	Short Term Memory; Associative Learning; Conditioning; Olfactory Perception; Sensory Training; Sensory Experience; Animals; Stimuli; Persistence + Suchen Sie Ihr Suchwort? Kurzzeitgedächtnis; Sensorische Erziehung; Sinnerfahrung; Animal; Tier; Tiere; Anreizsystem; Ausdauer
Abstract	In conditioned odor aversion (COA), the association of a tasteless odorized solution (the conditioned stimulus [CS]) with an intraperitoneal injection of LiCl (the unconditioned stimulus [US]), which produces visceral malaise, results in its future avoidance. The strength of this associative memory is mainly dependent on two parameters, that is, the strength of the US and the interstimuli interval (ISI). In rats, COA has been observed only with ISIs of [less than or equal to] 15 min and LiCl (0.15 M) doses of 2.0% of bodyweight, when tested 48 h after acquisition (long-term memory [LTM]). However, we previously reported a robust aversion in rats trained with ISIs up to 60 min when tested 4 h after acquisition (short-term memory [STM]). Since memories get reactivated during retrieval, in the current study we hypothesized that testing for STM would reactivate this COA trace, strengthening its LTM. For this, we compared the LTM of rats trained with long ISIs or low doses of LiCl initially tested for STM with that of rats tested for LTM only. Interestingly, rats conditioned under parameters sufficient to produce STM, but not LTM, showed a reliable LTM when first tested for STM. These observations suggest that under suboptimal training conditions, such as long ISIs or low US intensities, a CS-US association is established but requires reactivation in the short-term in order to persist in the long-term. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01