Novel Potential Link between Sleep Pattern Per3 Gene and Those with Insomnia in the Bermuda Population

Autor/in	Pacheco, Sierra
Titel	Novel Potential Link between Sleep Pattern Per3 Gene and Those with Insomnia in the Bermuda Population
Quelle	In: Voices in Education, 6 (2020), S.51-54 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	2059-0695
Schlagwörter	Foreign Countries; Genetics; Sleep; Correlation; Genetic Disorders; Ethnicity; Geographic Location; Bermuda; United Kingdom + Suchen Sie Ihr Suchwort? Ausland; Humangenetik; Schlaf; Korrelation; Ethnizität; Großbritannien
Abstract	The objective of this study was to assess the correlation of the Per3 gene VNTR polymorphism to insomnia patients in Bermuda. Buccal swabs were taken, and DNA was extracted, after which the genotypes of volunteers were characterised by using polymerase chain reaction. There were 25 total volunteers (21 females, 4 males, aged 20-79) that participated in the pilot study. 15 control volunteers and 10 insomniac volunteers. All volunteers with insomnia were classified by a pre-determined ICD-10 classification. Controls were those without any ICD-10 insomnia diagnosis. The frequency of the 4-repeat allele appears three times lower in insomniacs compared to the control group. However, this is not statistically significant in our sample size. When comparing our p-value of the Fisher's Exact Test to the cut off value of 5%, we see that there is not much difference, suggesting that a larger sample size could result in a significant result. When comparing the allele frequency for Bermudian insomniacs to the British patients with delayed sleep phase syndromes (DSPS), the 5-repeat allele is significantly higher (16 times greater) in Bermudian insomniacs. Thus, a larger sample size would distinguish if there is a statistical significance between those with insomnia and those without. Bermudian insomniacs vary distinctly in the Per3 allele frequencies to those in Britain with DSPS, suggesting a potential geographical or ethnic distinction. [With Carika Weldon.] (As Provided).
Anmerkungen	Bermuda College. 21 Stonington Avenue, Paget, Bermuda PG04. Tel: 441-236-9000; Fax: 441-239-4035; e-mail: bcjournal@college.bm; Web site: https://www.college.bm/index.php/about/bc-journal-voices-in-education
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01