Dorsolateral Striatum Engagement during Reversal Learning

Autor/inn/en	Bergstrom, Hadley C.; Lieberman, Abby G.; Graybeal, Carolyn; Lipkin, Anna M.; Holmes, Andrew
Titel	Dorsolateral Striatum Engagement during Reversal Learning
Quelle	In: Learning & Memory, 27 (2020) 10, S.418-422 (5 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Bergstrom, Hadley C.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.051714.120
Schlagwörter	Brain Hemisphere Functions; Stimuli; Responses; Learning Processes; Task Analysis; Decision Making; Animals; Rewards + Suchen Sie Ihr Suchwort? Anreizsystem; Learning process; Lernprozess; Aufgabenanalyse; Decision-making; Entscheidungsfindung; Animal; Tier; Tiere; Reward; Belohnung
Abstract	Most experimental preparations demonstrate a role for dorsolateral striatum (DLS) in stimulus-response, but not outcome-based, learning. Here, we assessed DLS involvement in a touchscreen-based reversal task requiring mice to update choice following a change in stimulus-reward contingencies. In vivo single-unit recordings in the DLS showed reversal produced a population-level shift from excited to inhibited neuronal activity prior to choices being made. The larger the shift, the faster mice reversed. Furthermore, optogenetic photosilencing DLS neurons during choice increased early reversal errors. These findings suggest dynamic DLS engagement may facilitate reversal, possibly by signaling a change in contingencies to other striatal and cortical regions. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01