Decreased Cued Fear Discrimination Learning in Female Rats as a Function of Estrous Phase

Autor/inn/en	Trask, Sydney; Reis, David S.; Ferrara, Nicole C.; Helmstetter, Fred J.
Titel	Decreased Cued Fear Discrimination Learning in Female Rats as a Function of Estrous Phase
Quelle	In: Learning & Memory, 27 (2020) 6, S.254-257 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Animals; Gender Differences; Metabolism; Fear; Cues; Generalization; Biochemistry + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Geschlechterkonflikt; Stoffwechsel; Furcht; Stichwort; Biochemie
Abstract	Relative to males, female rats can show enhanced contextual fear generalization (demonstrating a fear response in a safe or neutral context) dependent on estrogen receptor activation. The current experiment aimed to extend this finding to cued fear conditioning. Females in low-estrogen phases of the estrous cycle showed good discrimination, similar to males, between a conditional stimulus that predicted shock (CS+) and an equally familiar one that did not (CS-), while females in the proestrus (high estrogen) phase demonstrated similar levels of fear between the CS+ and CS-. These results demonstrate that cued fear generalization is similarly influenced by endogenous estrogens. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01