Neural Features of Sustained Emotional Information Processing in Autism Spectrum Disorder

Autor/inn/en	Mazefsky, Carla A.; Collier, Amanda; Golt, Josh; Siegle, Greg J.
Titel	Neural Features of Sustained Emotional Information Processing in Autism Spectrum Disorder
Quelle	In: Autism: The International Journal of Research and Practice, 24 (2020) 4, S.941-953 (13 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Mazefsky, Carla A.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361320903137
Schlagwörter	Cognitive Processes; Emotional Response; Self Control; Information Processing; Autism; Pervasive Developmental Disorders; Adolescents; Brain Hemisphere Functions; Check Lists; Word Lists; Comorbidity; Repetition; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Cognitive process; Kognitiver Prozess; Emotionales Verhalten; Selbstbeherrschung; Informationsverarbeitung; Autismus; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Checkliste; Wortliste; Wiederholung
Abstract	Emotion dysregulation is common in autism spectrum disorder; a better understanding of the underlying neural mechanisms could inform treatment development. The tendency toward repetitive cognition in autism spectrum disorder may also increase susceptibility to perseverate on distressing stimuli, which may then increase emotion dysregulation. Therefore, this study investigated the mechanisms of sustained processing of negative information in brain activity using functional magnetic resonance imaging. We used an event-related task that alternated between emotional processing of personally relevant negative words, neutral words, and a non-emotional task. A priori criteria were developed to define heightened and sustained emotional processing, and feature conjunction analysis was conducted to identify all regions satisfying these criteria. Participants included 25 adolescents with autism spectrum disorder and 23 IQ-, age-, and gender-matched typically developing controls. Regions satisfying all a priori criteria included areas in the salience network and the prefrontal dorsolateral cortex, which are areas implicated in emotion regulation outside of autism spectrum disorder. Collectively, activity in the identified regions accounted for a significant amount of variance in emotion dysregulation in the autism spectrum disorder group. Overall, these results may provide a potential neural mechanism to explain emotion dysregulation in autism spectrum disorder, which is a significant risk factor for poor mental health. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01