Cohesion of Cortical Language Networks during Word Processing Is Predicted by a Common Polymorphism in the "SETBP1" Gene

Autor/inn/en	Rakhlin, Natalia; Landi, Nicole; Lee, Maria; Magnuson, James S.; Naumova, Oxana Yu.; Ovchinnikova, Irina V.; Grigorenko, Elena L.
Titel	Cohesion of Cortical Language Networks during Word Processing Is Predicted by a Common Polymorphism in the "SETBP1" Gene
Quelle	In: New Directions for Child and Adolescent Development, (2020) 169, S.131-155 (25 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Rakhlin, Natalia) ORCID (Landi, Nicole)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1520-3247
DOI	10.1002/cad.20331
Schlagwörter	Genetics; Language Impairments; Developmental Delays; Correlation; Geographic Isolation; Brain Hemisphere Functions; Auditory Stimuli; Pictorial Stimuli; Task Analysis; Vocabulary; Etiology; Diagnostic Tests; Developmental Disabilities; Children; Adolescents + Suchen Sie Ihr Suchwort? Humangenetik; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Entwicklungsverzögerung; Korrelation; Auditive Stimulation; Fantasieanregung; Aufgabenanalyse; Wortschatz; Ätiologie; Diagnostic test; Diagnostischer Test; Entwicklungsstörung; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher
Abstract	The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome-wide association study of DLD in a geographically isolated population, and brain network-based endophenotypes of functional intracortical coherence between major language-related brain areas. We analyzed electroencephalogram (EEG) data from thirty-nine children (twenty-three with, sixteen without DLD) aged 7.17-15.83 years acquired during an auditory picture-word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the "SETBP1" gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p = 0.00478). This suggests that the development of these brain networks might be partially associated with the variation in "SETBP1." (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01