Literaturnachweis - Detailanzeige
| Autor/inn/en | Sekeres, Melanie J.; Moscovitch, Morris; Grady, Cheryl L.; Sullens, D. Gregory; Winocur, Gordon |
|---|---|
| Titel | Reminders Reinstate Context-Specificity to Generalized Remote Memories in Rats: Relation to Activity in the Hippocampus and aCC |
| Quelle | In: Learning & Memory, 27 (2020) 1, S.1-5 (5 Seiten)
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| Zusatzinformation | ORCID (Sekeres, Melanie J.) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 1072-0502 |
| DOI | 10.1101/lm.050161.119 |
| Schlagwörter | Memory; Animals; Brain Hemisphere Functions; Conditioning; Fear; Generalization; Context Effect; Comparative Analysis; Testing; Genetics; Cytology; Foreign Countries; Drug Therapy; Canada |
| Abstract | Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a no reminder condition. c-Fos expression in dorsal CA1 was observed following retrieval in the original context, but not in a novel context, whether or not the memory was reactivated, suggesting that dCA1 retains the context-specific representation. c-Fos was highly expressed in aCC following remote memory testing in both contexts, regardless of reminder condition, indicating that aCC develops generalized representations that are insensitive to memory reactivation. (As Provided). |
| Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
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