Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems--A Retrospective Feasibility Study

Autor/inn/en	Aran, Adi; Cassuto, Hanoch; Lubotzky, Asael; Wattad, Nadia; Hazan, Esther
Titel	Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems--A Retrospective Feasibility Study
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 3, S.1284-1288 (5 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Aran, Adi)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-018-3808-2
Schlagwörter	Behavior Problems; Autism; Pervasive Developmental Disorders; Sleep; Psychosis; Drug Therapy; Marijuana; Outcomes of Treatment; Parent Attitudes; Eating Habits; Patients + Suchen Sie Ihr Suchwort? Autismus; Schlaf; Psychose; Elternverhalten; Ernährungsgewohnheit; Essgewohnheit; Patient
Abstract	Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01