Literaturnachweis - Detailanzeige
Autor/inn/en | Wong, Edwin W.; Glasgow, Stephen D.; Trigiani, Lianne J.; Chitsaz, Daryan; Rymar, Vladimir; Sadikot, Abbas; Ruthazer, Edward S.; Hamel, Edith; Kennedy, Timothy E. |
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Titel | Spatial Memory Formation Requires Netrin-1 Expression by Neurons in the Adult Mammalian Brain |
Quelle | In: Learning & Memory, 26 (2019) 3, S.77-83 (7 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1072-0502 |
DOI | 10.1101/lm.049072.118 |
Schlagwörter | Spatial Ability; Memory; Adults; Brain; Foreign Countries; Animals; Brain Hemisphere Functions; Cues; Neurology; Canada (Montreal) |
Abstract | Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory. Here, we assessed the impact of neuronal expression of netrin-1 in the adult brain on behavior using tests of learning and memory. We show that adult mice exhibit impaired spatial memory following conditional deletion of netrin-1 from glutamatergic neurons in the hippocampus and neocortex. Further, we provide evidence that mice with conditional deletion of netrin-1 do not display aberrant anxiety-like phenotypes and show a reduction in self-grooming behavior. These findings reveal a critical role for netrin-1 expressed by neurons in the regulation of spatial memory formation. (As Provided). |
Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2020/1/01 |