Input from the Medial Geniculate Nucleus Modulates Amygdala Encoding of Fear Memory Discrimination

Autor/inn/en	Ferrara, Nicole C.; Cullen, Patrick K.; Pullins, Shane P.; Rotondo, Elena K.; Helmstetter, Fred J.
Titel	Input from the Medial Geniculate Nucleus Modulates Amygdala Encoding of Fear Memory Discrimination
Quelle	In: Learning & Memory, 24 (2017) 9, S.414-421 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.044131.116
Schlagwörter	Fear; Brain; Memory; Discrimination Learning; Generalization; Auditory Stimuli; Conditioning; Cues; Genetics; Neurology; Anxiety; Stress Variables; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Furcht; Gehirn; Gedächtnis; Lernen; Lernprozess; Auditive Stimulation; Stichwort; Humangenetik; Neurologie; Angst
Abstract	Generalization of fear can involve abnormal responding to cues that signal safety and is common in people diagnosed with post-traumatic stress disorder. Differential auditory fear conditioning can be used as a tool to measure changes in fear discrimination and generalization. Most prior work in this area has focused on elevated amygdala activity as a critical component underlying generalization. The amygdala receives input from auditory cortex as well as the medial geniculate nucleus (MgN) of the thalamus, and these synapses undergo plastic changes in response to fear conditioning and are major contributors to the formation of memory related to both safe and threatening cues. The requirement for MgN protein synthesis during auditory discrimination and generalization, as well as the role of MgN plasticity in amygdala encoding of discrimination or generalization, have not been directly tested. GluR1 and GluR2 containing AMPA receptors are found at synapses throughout the amygdala and their expression is persistently up-regulated after learning. Some of these receptors are postsynaptic to terminals from MgN neurons. We found that protein synthesis-dependent plasticity in MgN is necessary for elevated freezing to both aversive and safe auditory cues, and that this is accompanied by changes in the expressions of AMPA receptor and synaptic scaffolding proteins (e.g., SHANK) at amygdala synapses. This work contributes to understanding the neural mechanisms underlying increased fear to safety signals after stress. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01