d Subunit-Containing GABA[subscript A] Receptor Prevents Overgeneralization of Fear in Adult Mice

Autor/inn/en	Zhang, Wen-Hua; Zhou, Jin; Pan, Han-Qing; Wang, Xiao-Yang; Liu, Wei-Zhu; Zhang, Jun-Yu; Yin, Xiao-Ping; Pan, Bing-Xing
Titel	d Subunit-Containing GABA[subscript A] Receptor Prevents Overgeneralization of Fear in Adult Mice
Quelle	In: Learning & Memory, 24 (2017) 8, S.381-384 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045856.117
Schlagwörter	Adults; Animals; Fear; Brain; Genetics; Neurological Organization; Stimuli; Generalization + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Furcht; Gehirn; Humangenetik; Anreizsystem
Abstract	The role of d subunit-containing GABA[subscript A] receptor (GABA[subscript A](d)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion of GABA[subscript A](d)R and using protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, we observed that when the two tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more than their wild-type littermates to the nonconditioned but not conditioned stimuli. Thus, GABA[subscript A](d)R may prevent inappropriate fear generalization when the incoming stimuli differ clearly from the learned threat. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01