Updating of Aversive Memories after Temporal Error Detection Is Differentially Modulated by mTOR across Development

Autor/inn/en	Tallot, Lucille; Diaz-Mataix, Lorenzo; Perry, Rosemarie E.; Wood, Kira; LeDoux, Joseph E.; Mouly, Anne-Marie; Sullivan, Regina M.; Doyère, Valérie
Titel	Updating of Aversive Memories after Temporal Error Detection Is Differentially Modulated by mTOR across Development
Quelle	In: Learning & Memory, 24 (2017) 3, S.115-122 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.043083.116
Schlagwörter	Long Term Memory; Error Patterns; Cognitive Processes; Brain; Prediction; Conditioning; Stimuli; Animals; Associative Learning + Suchen Sie Ihr Suchwort? Langzeitgedächtnis; Fehlertyp; Cognitive process; Kognitiver Prozess; Gehirn; Vorhersage; Anreizsystem; Animal; Tier; Tiere
Abstract	The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats, prediction error detection and its associated protein synthesis-dependent reconsolidation can be triggered by reactivating the memory with the conditioned stimulus (CS), but without the unconditioned stimulus (US), or by presenting a CS-US pairing with a different CS-US interval than during the initial learning. Whether similar mechanisms underlie memory updating in the young is not known. Using similar paradigms with rapamycin (an mTORC1 inhibitor), we show that preweaning rats (PN18-20) do form a long-term memory of the CS-US interval, and detect a 10-sec versus 30-sec temporal prediction error. However, the resulting updating/reconsolidation processes become adult-like after adolescence (PN30-40). Our results thus show that while temporal prediction error detection exists in preweaning rats, specific infant-type mechanisms are at play for associative learning and memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01