Stability and Change in Autism Spectrum Disorder Diagnosis from Age 3 to Middle Childhood in a High-Risk Sibling Cohort

Autor/inn/en	Brian, Jessica; Bryson, Susan E.; Smith, Isabel M.; Roberts, Wendy; Roncadin, Caroline; Szatmari, Peter; Zwaigenbaum, Lonnie
Titel	Stability and Change in Autism Spectrum Disorder Diagnosis from Age 3 to Middle Childhood in a High-Risk Sibling Cohort
Quelle	In: Autism: The International Journal of Research and Practice, 20 (2016) 7, S.888-892 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361315614979
Schlagwörter	Autism; Pervasive Developmental Disorders; Clinical Diagnosis; Toddlers; Children; Classification; Symptoms (Individual Disorders); Evaluation Criteria; Siblings; At Risk Persons; Receptive Language; Child Development; Change; Diagnostic Tests; Observation; Multivariate Analysis; Autism Diagnostic Observation Schedule + Suchen Sie Ihr Suchwort? Autismus; Infant; Infants; Toddler; Kleinkind; Child; Kind; Kinder; Classification system; Klassifikation; Klassifikationssystem; Psychiatrische Symptomatik; Sibling; Geschwister; Risikogruppe; Rezeptive Kommunikationsfähigkeit; Kindesentwicklung; Wandel; Diagnostic test; Diagnostischer Test; Beobachtung; Multivariate Analyse
Abstract	Considerable evidence on autism spectrum disorder emergence comes from longitudinal high-risk samples (i.e. younger siblings of children with autism spectrum disorder). Diagnostic stability to age 3 is very good when diagnosed as early as 18-24 months, but sensitivity is weaker, and relatively little is known beyond toddlerhood. We examined stability and change in blinded, clinical best-estimate diagnosis from age 3 to middle childhood (mean age = 9.5 years) in 67 high-risk siblings enrolled in infancy. Good agreement emerged for clinical best-estimate diagnoses (89.6% overall; kappa = 0.76, p < 0.001, 95% confidence interval = 0.59-0.93). At age 3, 18 cases (26.9%) were classified with "autism spectrum disorder": 17 retained their autism spectrum disorder diagnosis (94.4%; 13 boys, 4 girls) and 1 no longer met autism spectrum disorder criteria at follow-up. Among "non-autism spectrum disorder" cases at age 3, 43/49 remained non--autism spectrum disorder at follow-up (87.8%; 22 boys, 21 girls) and 6/49 met lower autism symptomatology criteria ("Later-Diagnosed"; 3 boys, 3 girls). Later-diagnosed cases had significantly lower autism spectrum disorder symptomatology and higher receptive language at age 3 and trends toward lower autism symptoms and higher cognitive abilities at follow-up. Emerging developmental concerns were noted in all later-diagnosed cases, by age 3 or 5. High-risk children need to be followed up into middle childhood, particularly when showing differences in autism-related domains. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01