Preconceptional and Prenatal Supplementary Folic Acid and Multivitamin Intake and Autism Spectrum Disorders

Autor/inn/en	Virk, Jasveer; Liew, Zeyan; Olsen, Jørn; Nohr, Ellen A.; Catov, Janet M.; Ritz, Beate
Titel	Preconceptional and Prenatal Supplementary Folic Acid and Multivitamin Intake and Autism Spectrum Disorders
Quelle	In: Autism: The International Journal of Research and Practice, 20 (2016) 6, S.710-718 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361315604076
Schlagwörter	Autism; Pervasive Developmental Disorders; Pregnancy; Nutrition; Prevention; Risk Assessment; Dietetics; Correlation; Asperger Syndrome; Females; Mothers; Prenatal Influences; Foreign Countries; California (Los Angeles); Denmark + Suchen Sie Ihr Suchwort? Autismus; Schwangerschaft; Ernährung; Prävention; Vorbeugung; Risikoabschätzung; Ernährungslehre; Korrelation; Asperger-Syndrom; Weibliches Geschlecht; Mother; Mutter; Pränataler Einfluss; Ausland; Dänemark
Abstract	Objective: To evaluate whether early folic acid supplementation during pregnancy prevents diagnosis of autism spectrum disorders in offspring. Methods: Information on autism spectrum disorder diagnosis was obtained from the National Hospital Register and the Central Psychiatric Register. We estimated risk ratios for autism spectrum disorders for children whose mothers took folate or multivitamin supplements from 4 weeks prior from the last menstrual period through to 8 weeks after the last menstrual period (-4 to 8 weeks) by three 4-week periods. Results: We did not find an association between early folate or multivitamin intake for autism spectrum disorder (folic acid--adjusted risk ratio: 1.06, 95% confidence interval: 0.82-1.36; multivitamin--adjusted risk ratio: 1.00, 95% confidence interval: 0.82-1.22), autistic disorder (folic acid--adjusted risk ratio: 1.18, 95% confidence interval: 0.76-1.84; multivitamin--adjusted risk ratio: 1.22, 95% confidence interval: 0.87-1.69), Asperger's syndrome (folic acid--adjusted risk ratio: 0.85, 95% confidence interval: 0.46-1.53; multivitamin--adjusted risk ratio: 0.95, 95% confidence interval: 0.62-1.46), or pervasive developmental disorder--not otherwise specified (folic acid--adjusted risk ratio: 1.07, 95% confidence interval: 0.75-1.54; multivitamin--adjusted risk ratio: 0.87, 95% confidence interval: 0.65-1.17) compared with women reporting no supplement use in the same period. Conclusion: We did not find any evidence to corroborate previous reports of a reduced risk for autism spectrum disorders in offspring of women using folic acid supplements in early pregnancy. (As Provided).
Anmerkungen	SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: http://sagepub.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01