Brief Report: Phenotypic Differences and Their Relationship to Paternal Age and Gender in Autism Spectrum Disorder

Autor/inn/en	Vierck, Esther; Silverman, Jeremy M.
Titel	Brief Report: Phenotypic Differences and Their Relationship to Paternal Age and Gender in Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 45 (2015) 6, S.1915-1924 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-014-2346-9
Schlagwörter	Autism; Pervasive Developmental Disorders; Differences; Fathers; Age; Sex; Genetics; Intelligence Quotient; Adjustment (to Environment); Symptoms (Individual Disorders); Multiple Regression Analysis + Suchen Sie Ihr Suchwort? Autismus; Unterscheiden; Alter; Lebensalter; Geschlecht; Geschlechtsverkehr; Humangenetik; Intelligenzquotient; Psychiatrische Symptomatik
Abstract	Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01