The 5-HT[subscript 3A] Receptor Is Essential for Fear Extinction

Autor/inn/en	Kondo, Makoto; Nakamura, Yukiko; Ishida, Yusuke; Yamada, Takahiro; Shimada, Shoichi
Titel	The 5-HT[subscript 3A] Receptor Is Essential for Fear Extinction
Quelle	In: Learning & Memory, 21 (2014) 1, S.1-4 (4 Seiten) PDF als Volltext Verfügbarkeit
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.032193.113
Schlagwörter	Fear; Memory; Cognitive Psychology; Cognitive Processes; Animals; Conditioning; Brain Hemisphere Functions; Molecular Structure; Neurological Organization + Suchen Sie Ihr Suchwort? Furcht; Gedächtnis; Kognitive Psychologie; Cognitive process; Kognitiver Prozess; Animal; Tier; Tiere
Abstract	The 5-HT [subscript 3] receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT [subscript 3A] receptor knockout mice in fear conditioning paradigms revealed that the 5-HT [subscript 3A] receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT [subscript 3A] receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10