Deletion of PTEN Produces Deficits in Conditioned Fear and Increases Fragile X Mental Retardation Protein

Autor/inn/en	Lugo, Joaquin N.; Smith, Gregory D.; Morrison, Jessica B.; White, Jessika
Titel	Deletion of PTEN Produces Deficits in Conditioned Fear and Increases Fragile X Mental Retardation Protein
Quelle	In: Learning & Memory, 20 (2013) 12, S.670-673 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.032839.113
Schlagwörter	Fear; Conditioning; Mental Retardation; Genetic Disorders; Memory; Neurological Impairments; Animals; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Furcht; Geistige Behinderung; Gedächtnis; Neurodegenerative Erkrankung; Animal; Tier; Tiere
Abstract	The phosphatase and tensin homolog detected on chromosome 10 (PTEN) gene product modulates activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. The PI3K pathway has been found to be involved in the regulation of the fragile X mental retardation protein, which is important for long-term depression and in the formation of new memories. We used delayed fear conditioning and trace fear conditioning to determine learning and memory deficits in neuron subset-specific Pten (NS-Pten) conditional knockout (KO) mice. We found that NS-Pten KO mice had deficits in contextual learning and trace conditioning, but did not have deficits in the ability to learn a conditioned stimulus. Furthermore, we found increased levels in the total and phosphorylated forms of the fragile X mental retardation protein (FMRP) in the hippocampus of NS-Pten KO mice. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10