Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links with Pragmatic Language

Autor/inn/en	Klusek, Jessica; Martin, Gary E.; Losh, Molly
Titel	Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links with Pragmatic Language
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 118 (2013) 6, S.475-495 (21 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
DOI	10.1352/1944.7558-118.6.475
Schlagwörter	Physiology; Genetic Disorders; Pervasive Developmental Disorders; Autism; Males; Comparative Analysis; Arousal Patterns; Language Impairments; Social Development; Receptive Language; Expressive Language; Mental Retardation + Suchen Sie Ihr Suchwort? Physiologie; Autismus; Male; Männliches Geschlecht; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Soziale Entwicklung; Rezeptive Kommunikationsfähigkeit; Geistige Behinderung
Abstract	This study tested the hypothesis that pragmatic (i.e., social) language impairment is linked to arousal dysregulation in autism spectrum disorder (ASD) and fragile X syndrome (FXS). Forty boys with ASD, 39 with FXS, and 27 with typical development (TD), aged 4-15 years, participated. Boys with FXS were hyperaroused compared to boys with TD but did not differ from boys with ASD. Dampened vagal tone predicted pragmatic impairment in ASD, and associations emerged between cardiac activity and receptive/expressive vocabulary across groups. Findings support autonomic dysfunction as a mechanism underlying pragmatic impairment in ASD and suggest that biophysiological profiles are shared in ASD and FXS, which has implications for understanding the role of "fragile X mental retardation-1" ("FMR1," the FXS gene) in the pathophysiology of ASD. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10