Differential Susceptibility to Prevention: GABAergic, Dopaminergic, and Multilocus Effects

Autor/inn/en	Brody, Gene H.; Chen, Yi-fu; Beach, Steven R. H.
Titel	Differential Susceptibility to Prevention: GABAergic, Dopaminergic, and Multilocus Effects
Quelle	In: Journal of Child Psychology and Psychiatry, 54 (2013) 8, S.863-871 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/jcpp.12042
Schlagwörter	Prevention; Genetics; Drinking; At Risk Persons; African Americans; Preadolescents; Rural Population; Participation; Longitudinal Studies; Georgia + Suchen Sie Ihr Suchwort? Prävention; Vorbeugung; Humangenetik; Trinken; Risikogruppe; Afroamerikaner; Pre-adolescence; Präadoleszenz; Landbevölkerung; Teilnahme; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung
Abstract	Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than 900 youths to determine whether prevention program participation would, across 2 years, moderate genetic risk for increased alcohol use conferred by the dopaminergic and GABAergic systems. Results: We found that (a) variance in dopaminergic ("DRD2, DRD4, ANKK1") and GABAergic ("GABRG1, GABRA2") genes forecast increases in alcohol use across 2 years, and (b) youths at genetic risk who were assigned to the control condition displayed greater increases in alcohol use across 2 years than did youths at genetic risk who were assigned to the prevention condition or youths without genetic risk who were assigned to either condition. Conclusions: This study is unique in combining data from two large prevention trials to test hypotheses regarding genetic main effects and gene [variable] prevention interactions. Focusing on gene systems purported to confer risk for alcohol use and abuse, the study demonstrated that participation in efficacious prevention programs can moderate genetic risk. The results also support the differential susceptibility hypothesis that some youths, for genetic reasons, are more susceptible than others to both positive and negative contextual influences. (Contains 2 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10