Hydrocortisone Infusion Exerts Dose- and Sex-Dependent Effects on Attention to Emotional Stimuli

Autor/inn/en	Breitberg, Alaina; Drevets, Wayne C.; Wood, Suzanne E.; Mah, Linda; Schulkin, Jay; Sahakian, Barbara J.; Erickson, Kristine
Titel	Hydrocortisone Infusion Exerts Dose- and Sex-Dependent Effects on Attention to Emotional Stimuli
Quelle	In: Brain and Cognition, 81 (2013) 2, S.247-255 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2012.10.010
Schlagwörter	Stimuli; Cognitive Processes; Reaction Time; Short Term Memory; Spatial Ability; Task Analysis; Drug Use; Attention; Language Usage; Diagnostic Tests; Gender Differences; Age Differences; Emotional Response + Suchen Sie Ihr Suchwort? Anreizsystem; Cognitive process; Kognitiver Prozess; Reaktionsvermögen; Kurzzeitgedächtnis; Räumliches Vorstellungsvermögen; Aufgabenanalyse; Drug consumption; Substance abuse; Drogenkonsum; Aufmerksamkeit; Sprachgebrauch; Diagnostic test; Diagnostischer Test; Geschlechterkonflikt; Age; Difference; Age difference; Altersunterschied; Emotionales Verhalten
Abstract	Glucocorticoid administration has been shown to exert complex effects on cognitive and emotional processing. In the current study we investigated the effects of glucocorticoid administration on attention towards emotional words, using an Affective Go/No-go task on which healthy humans have shown an attentional bias towards positive as compared to negative words. Healthy volunteers received placebo and either low-dose (0.15 mg/kg) or high-dose (0.45 mg/kg) hydrocortisone intravenously during two separate visits in a double-blind, randomized design. Seventy-five minutes post-infusion, the subjects performed tests of attention (Rapid Visual Information Processing [RVIP]), spatial working memory (Spatial Span) and emotional processing (Affective Go/No-go task [AGNG]). On the attention task, performance was impaired under both hydrocortisone doses relative to placebo, though the effect on error rate was not significant after controlling for age; Spatial Span performance was unaffected by hydrocortisone administration. On the AGNG task, relative to the placebo condition the low-dose hydrocortisone infusion decreased response time to emotional words while high-dose hydrocortisone increased response time. In the females specifically, both high and low dose hydrocortisone administration attenuated the normal attentional bias toward positively valenced words. These data suggest that, in healthy women, the modulation of attention by the emotional salience of stimuli is influenced by glucocorticoid hormone concentrations. (Contains 3 tables and 1 figure.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10