Olfactory Bulb [alpha][subscript 2]-Adrenoceptor Activation Promotes Rat Pup Odor-Preference Learning via a cAMP-Independent Mechanism

Autor/inn/en	Shakhawat, Amin MD.; Harley, Carolyn W.; Yuan, Qi
Titel	Olfactory Bulb [alpha][subscript 2]-Adrenoceptor Activation Promotes Rat Pup Odor-Preference Learning via a cAMP-Independent Mechanism
Quelle	In: Learning & Memory, 19 (2012) 11, S.499-502 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.027359.112
Schlagwörter	Evolution; Olfactory Perception; Animals; Role; Biochemistry; Sensory Experience; Learning Processes; Drug Use; Cytology; Stimuli + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Rollen; Biochemie; Sinnerfahrung; Learning process; Lernprozess; Drug consumption; Substance abuse; Drogenkonsum; Zytologie; Anreizsystem
Abstract	In this study, three lines of evidence suggest a role for [alpha][subscript 2]-adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the [alpha][subscript 2]-antagonist, yohimbine, prevents learning; the [alpha][subscript 2]-agonist, clonidine, paired with odor, induces learning; and subthreshold clonidine paired with subthreshold [beta]-adrenoceptor activation also recruits learning. Increased mitral cell layer pCREB occurs with clonidine-infusion, but cAMP is not increased. Similar results using a GABAa-antagonist suggest that disinhibition may support clonidine-induced learning. We suggest that norepinephrine can act through multiple bulbar adrenoceptor subtypes to induce odor learning and that cAMP-dependent, as well as cAMP-independent, signals may act as unconditioned stimuli. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10