Literaturnachweis - Detailanzeige
| Autor/inn/en | Bak, Thomas H.; Yancopoulou, Despina; Nestor, Peter J.; Xuereb, John H.; Spillantini, Maria G.; Pulvermuller, Friedemann; Hodges, John R. |
|---|---|
| Titel | Clinical, Imaging and Pathological Correlates of a Hereditary Deficit in Verb and Action Processing |
| Quelle | In: Brain, 129 (2006) 2, S.321-332 (12 Seiten)
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| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0006-8950 |
| DOI | 10.1093/brain/awh701 |
| Schlagwörter | Dementia; Verbs; Pathology; Nouns; Genetics; Cerebral Palsy; Vocabulary; Neurological Impairments; Brain; Cognitive Processes; Language Processing; Neurology; Longitudinal Studies |
| Abstract | Selective verb and noun deficits have been observed in a number of neurological conditions and their occurrence has been interpreted as evidence for different neural networks underlying the processing of specific word categories. We describe the first case of a familial occurrence of a selective deficit of verb processing. Father (Individual I) and son (Individual II) developed a movement disorder resembling progressive supranuclear palsy (PSP) and associated with dementia. A second child of Individual II remained symptom-free on consecutive examinations. The dissociation between the processing of nouns and verbs in Individuals I and II was confirmed with different methods, including a longitudinal assessment of naming, comprehension, picture and word association, as well as a lexical decision task. The difference remained stable on follow-up testing despite overall deterioration. It was associated with left-sided frontal hypometabolism on FDG-PET imaging (Individual II) and with ubiquitin-positive inclusions on post-mortem examination (Individual I). The association of a selective verb deficit with a familial movement disorder raises the question whether related genetic factors might influence both movements and their abstract conceptual representations in the form of action verbs. By demonstrating a link between pathology, genetics, imaging and abstract cognitive impairments this study advances our understanding of degenerative brain disease with implications for both neuroscience and clinical practice. (Author). |
| Anmerkungen | Oxford University Press. Great Clarendon Street, Oxford, OX2 6DP, UK. Tel: +44-1865-353907; Fax: +44-1865-353485; e-mail: jnls.cust.serv@oxfordjournals.org; Web site: http://brain.oxfordjournals.org/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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