An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism

Autor/inn/en	Giannotti, F.; Cortesi, F.; Cerquiglini, A.; Bernabei, P.
Titel	An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism
Quelle	In: Journal of Autism and Developmental Disorders, 36 (2006) 6, S.741-752 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-006-0116-z
Schlagwörter	Autism; Sleep; Young Children; Pathology; Questionnaires; Outcomes of Treatment; Comparative Analysis; Diaries; Drug Therapy + Suchen Sie Ihr Suchwort? Autismus; Schlaf; Frühe Kindheit; Pathologie; Fragebogen; Diary; Tagebuch
Abstract	Long-term effectiveness of controlled-release melatonin in 25 children, aged 2.6-9.6 years with autism without other coexistent pathologies was evaluated openly. Sleep patterns were studied using Children's Sleep Habits Questionnaire (CSHQ) and sleep diaries at baseline, after 1-3-6 months melatonin treatment and 1 month after discontinuation. Sleep diary and CSHQ showed a more problematic sleep in autistic children compared with controls. During treatment sleep patterns of all children improved. After discontinuation 16 children returned to pre-treatment score, readministration of melatonin was again effective. Treatment gains were maintained at 12 and 24-month follow-ups. No adverse side effects were reported. In conclusion, controlled-release melatonin may provide an effective and well-tolerated treatment for autistic children with chronic sleep disorders. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10