3D Mapping of Language Networks in Clinical and Pre-Clinical Alzheimer's Disease

Autor/inn/en	Apostolova, Liana G.; Lu, Po; Rogers, Steve; Dutton, Rebecca A.; Hayashi, Kiralee M.; Toga, Arthur W.; Cummings, Jeffrey L.; Thompson, Paul M.
Titel	3D Mapping of Language Networks in Clinical and Pre-Clinical Alzheimer's Disease
Quelle	In: Brain and Language, 104 (2008) 1, S.33-41 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0093-934X
DOI	10.1016/j.bandl.2007.03.008
Schlagwörter	Animals; Brain Hemisphere Functions; Alzheimers Disease; Language Impairments; Patients; Regression (Statistics); Organizations (Groups); Ethology; Computational Linguistics; Concept Mapping; Neurolinguistics; Language Fluency + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Patient; Regression; Regressionsanalyse; Ethologie; Linguistics; Computerlinguistik; Concept Map; Neurolinguistisches Programmieren; Language skill; Language skills; Sprachkompetenz
Abstract	We investigated the associations between Boston naming and the animal fluency tests and cortical atrophy in 19 probable AD and 5 multiple domain amnestic mild cognitive impairment patients who later converted to AD. We applied a surface-based computational anatomy technique to MRI scans of the brain and then used linear regression models to detect associations between animal fluency and Boston Naming Test (BNT) performance and cortical atrophy. The global permutation-corrected significance for the maps associating BNT performance with cortical atrophy was p=0.0124 for the left and p=0.0196 for the right hemisphere and for the animal fluency maps p=.055 for the left and p=0.073 for the right hemisphere. The degree of language impairment correlated with cortical atrophy in the left temporal and parietal lobes (BA 20, 21, 37, 39, 40, and 7), bilateral frontal lobes (BA 8, 9, and 44) and the right temporal pole (BA 38). Using a novel 3D mapping technique, we demonstrated that in AD language abilities are strongly influenced by the integrity of the perisylvian cortical regions. (Author).
Anmerkungen	Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10