Pituitary Volume Prospectively Predicts Internalizing Symptoms in Adolescence

Autor/inn/en	Zipursky, Amy R.; Whittle, Sarah; Yucel, Murat; Lorenzetti, Valentina; Wood, Stephen J.; Lubman, Dan I.; Simmons, Julian G.; Allen, Nicholas B.
Titel	Pituitary Volume Prospectively Predicts Internalizing Symptoms in Adolescence
Quelle	In: Journal of Child Psychology and Psychiatry, 52 (2011) 3, S.315-323 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2010.02337.x
Schlagwörter	Physiology; Early Adolescents; Rating Scales; Regression (Statistics); Symptoms (Individual Disorders); Behavior Problems; Longitudinal Studies; Interviews; Diagnostic Tests; Prediction; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Physiologie; Rating-Skala; Regression; Regressionsanalyse; Psychiatrische Symptomatik; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Interviewing; Interviewtechnik; Diagnostic test; Diagnostischer Test; Vorhersage
Abstract	Background: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic-pituitary-adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence using a prospective, longitudinal design. Methods: One hundred and fifty-five adolescents completed 3T structural magnetic resonance imaging (MRI), symptom rating scales and a diagnostic interview during early adolescence (M age 12.6 years, SD 0.5 years); symptom rating scales were re-administered approximately three years later (M age 15.2 years). The volume of the pituitary gland was estimated by manually delineating its structure on MR images. The degree to which pituitary volumes prospectively predicted change in internalizing and externalizing symptoms across the two time-points was assessed using hierarchal linear regression, after controlling for the influence of gender, age, pubertal stage and intracranial volume. Results: Larger pituitary volumes prospectively predicted an increase in internalizing, but not externalizing, symptoms from early adolescence to mid-adolescence. Conclusions: This study provides the first evidence that increased pituitary volume might represent a specific vulnerability marker for the development of internalizing symptoms during early to mid-adolescence. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10