Pharmacological Treatment of Sleep Disturbance in Developmental Disabilities: A Review of the Literature

Autor/inn/en	Hollway, Jill A.; Aman, Michael G.
Titel	Pharmacological Treatment of Sleep Disturbance in Developmental Disabilities: A Review of the Literature
Quelle	In: Research in Developmental Disabilities: A Multidisciplinary Journal, 32 (2011) 3, S.939-962 (24 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0891-4222
DOI	10.1016/j.ridd.2010.12.035
Schlagwörter	Developmental Disabilities; Behavior Modification; Sleep; Drug Therapy; Literature Reviews; Evaluation Methods; Children + Suchen Sie Ihr Suchwort? Entwicklungsstörung; Behaviour modification; Verhaltensänderung; Schlaf; Child; Kind; Kinder
Abstract	Sleep disturbance is a common problem in children with developmental disabilities. Effective pharmacologic interventions are needed to ameliorate sleep problems that persist when behavior therapy alone is insufficient. The aim of the present study was to provide an overview of the quantity and quality of pharmacologic research targeting sleep in children with developmental disabilities. Efficacy studies of medications most likely to be prescribed to children are reviewed in detail. Medline and PsychInfo searches were performed to identify relevant clinical trials and case reports, published between 1975 and 2009. Key search terms included sleep, children, antihistamines, alpha adrenergic agonists, antidepressants, antipsychotics, melatonin, ramelteon, benzodiazepines, and nonbenzodiazepines. The literature search identified 58 articles that met the inclusion criteria. Well-controlled studies employing both objective polysomnography and subjective sleep measures are needed to determine the efficacy and safety of currently prescribed pediatric sleep medicines. Melatonin appears to be the most widely assessed agent and safest choice for children with developmental disabilities. Trazodone, mirtazapine, and ramelteon hold promise but require further study. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10