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Autor/inn/enWoodard, Cooper; Groden, June; Goodwin, Matthew; Bodfish, James
TitelA Placebo Double-Blind Pilot Study of Dextromethorphan for Problematic Behaviors in Children with Autism
QuelleIn: Autism: The International Journal of Research & Practice, 11 (2007) 1, S.29-41 (13 Seiten)
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Spracheenglisch
Dokumenttypgedruckt; online; Zeitschriftenaufsatz
ISSN1362-3613
DOI10.1177/1362361307070989
SchlagwörterDrug Therapy; Behavior Problems; Symptoms (Individual Disorders); Children; Autism; Check Lists; Attention Deficit Disorders; Outcomes of Treatment; Data Analysis; Hyperactivity; Aberrant Behavior Checklist
AbstractWe used a mixed group/single-case, double-blind, placebo-controlled, ABAB design to examine the safety and efficacy of the glutamate antagonist dextromethorphan for the treatment of problematic behaviors and core symptoms in eight children diagnosed with autism. All participants had increased levels of irritability at baseline as measured by the Aberrant Behavior Checklist, and demonstrated a wide variety of problematic behaviors. Group analyses revealed that dextromethorphan was equivalent to placebo in the treatment of problem behaviors and core symptoms. Analyses at the single-subject level demonstrated that three of the eight participants who had a behavioral profile consistent with attention-deficit hyperactivity disorder responded positively to dextromethorphan. Future research that employs a larger, more homogeneous sample is necessary to replicate the findings from this study. (Contains 3 tables and 2 figures.) (Author).
AnmerkungenSAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: http://sagepub.com
Erfasst vonERIC (Education Resources Information Center), Washington, DC
Update2017/4/10
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