Comorbidity Rates of Autism Spectrum Disorder and Functional Neurological Disorders: A Systematic Review, Meta-Analysis of Proportions and Qualitative Synthesis

Autor/inn/en	Mark L. Vickers; Rebecca Sue Menhinnitt; Yoon Kwon Choi; Eva Malacova; Lars Eriksson; Agesilaus W. Churchill; Belinda Oddy; Kym Boon; Christopher Randall; Anastasia Braun; Jennifer Taggart; Rodney Marsh; Paul Pun
Titel	Comorbidity Rates of Autism Spectrum Disorder and Functional Neurological Disorders: A Systematic Review, Meta-Analysis of Proportions and Qualitative Synthesis
Quelle	In: Autism: The International Journal of Research and Practice, 29 (2025) 2, S. 344-354 PDF als Volltext Link als defekt meldenVerfügbarkeit
Zusatzinformation	ORCID (Mark L. Vickers) ORCID (Yoon Kwon Choi)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/13623613241272958
Schlagwörter	Forschungsbericht; Comorbidity; Neurological Impairments; Autism Spectrum Disorders; Meta Analysis; Incidence; Patients; Research Reports; Case Studies; Seizures; Symptoms (Individual Disorders); Adults; Psychomotor Skills; Therapy; Risk; Mental Disorders; Clinical Diagnosis; Children; Adolescents + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Autism; Autismus; Meta-analysis; Metaanalyse; Vorkommen; Patient; Research report; Forschungsbericht; Case study; Fallstudie; Case Study; Anfallsleiden; Psychiatrische Symptomatik; Psychomotorische Aktivität; Therapie; Risiko; Mental illness; Geisteskrankheit; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher
Abstract	This study evaluated the comorbidity rates of autism spectrum disorder (ASD) with functional neurological disorders (FNDs). A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A subset of data was suitable for meta-analysis of proportions. Studies which assessed either the prevalence of ASD in patients with FNDs, or the prevalence of FNDs in patients with ASD were considered. Critical appraisal was conducted using Joanna Briggs Institute Critical Appraisal Tools. Fourteen studies met the inclusion criteria. Three cross-sectional studies which reported the comorbidity of ASD among children presenting with functional seizures met inclusion for meta-analysis. The pooled comorbidity rate of ASD in this group was 10.26% [3.92, 18.95], with an I2 value of 81%, indicating significant heterogeneity between studies. Most included studies (n = 5) reported on the rates of Somatic Symptom Disorders in adults with ASD. Comorbidity rates were also reported for ASD with Functional Motor Disorders and for mixed FND cohorts. Critical appraisal indicated that studies were underpowered, did not match cases with controls and failed to account for confounding factors. Identifying ASD and FND comorbidity may guide treatment options and reduce the risks of unnecessary medical investigations. (As Provided).
Anmerkungen	SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com
Begutachtung	Peer reviewed
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2025/3/08