D1/5 Dopamine Receptors Are Necessary for Learning a Novel Context

Autor/inn/en	Sayegh, Fares; Herraiz, Laurie; Colom, Morgane; Lopez, Sébastien; Rampon, Claire; Dahan, Lionel
Titel	D1/5 Dopamine Receptors Are Necessary for Learning a Novel Context
Quelle	In: Learning & Memory, 29 (2022) 6, S.142-145 (4 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Sayegh, Fares) ORCID (Rampon, Claire) ORCID (Dahan, Lionel)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Cognitive Processes; Memory; Fear; Conditioning; Brain Hemisphere Functions; Neurological Organization; Biochemistry + Suchen Sie Ihr Suchwort? Cognitive process; Kognitiver Prozess; Gedächtnis; Furcht; Biochemie
Abstract	Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal injection only impairs contextual fear conditioning. By using the context pre-exposure facilitation effect test, we show that SCH23390 is able to block the encoding of the context during the pre-exposure phase. Thus, we provide additional evidence that dopamine is involved in encoding conjunctive representations of new contexts. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2022/4/11