Genetic Analysis of "UGT1A1" Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children

Autor/inn/en	Horinouchi, Tomoko; Maeyama, Kaori; Nagai, Masashi; Mizobuchi, Masami; Takagi, Yasuko; Okada, Yuka; Kato, Takeshi; Nishimura, Mio; Kawasaki, Yoko; Yoshioka, Mieko; Takada, Satoshi; Matsumoto, Hisayuki; Nakamachi, Yuji; Saegusa, Jun; Fukushima, Sachiyo; Fujioka, Kazumichi; Tomioka, Kazumi; Nagase, Hiroaki; Nozu, Kandai; Iijima, Kazumoto; Nishimura, Noriyuki
Titel	Genetic Analysis of "UGT1A1" Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 2, S.483-489 (7 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Nishimura, Noriyuki)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-04941-w
Schlagwörter	Neonates; Physiology; Biochemistry; Children; At Risk Persons; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Neugeborenes Kind; Physiologie; Biochemie; Child; Kind; Kinder; Risikogruppe; Autismus; Psychiatrische Symptomatik
Abstract	Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for "UGT1A128" (c.-41-40dup), "UGT1A16" (c.211 G > A), and "UGT1A127" (c.686 C > A). The allele frequency of "UGT1A16" (OR = 1.34, p = 0.26) and "UGT1A128" (OR = 0.80, p = 0.54) and the prevalence of "UGT1A128/6" diplotypes did not differ significantly from those in the control population. No "UGT1A127" allele was detected in the subjects. ASD symptom assessment scores were not associated with "UGT1A128/6/27" genotypes or "UGT1A128/*6" diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01