Neurological Disorders in Autism: A Systematic Review and Meta-Analysis

Autor/inn/en	Pan, Pei-Yin; Bölte, Sven; Kaur, Preet; Jamil, Sadia; Jonsson, Ulf
Titel	Neurological Disorders in Autism: A Systematic Review and Meta-Analysis
Quelle	In: Autism: The International Journal of Research and Practice, 25 (2021) 3, S.812-830 (19 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Pan, Pei-Yin) ORCID (Bölte, Sven) ORCID (Jonsson, Ulf)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361320951370
Schlagwörter	Neurological Impairments; Autism; Pervasive Developmental Disorders; Meta Analysis; Etiology; Comorbidity; Epilepsy; Intellectual Disability; Cerebral Palsy; Congenital Impairments; Incidence + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Autismus; Meta-analysis; Metaanalyse; Ätiologie; Epilepsie; Intellect; Disability; Disabilities; Verstand; Behinderung; Hirnlähmung; Vorkommen
Abstract	The etiological significance of neurological disorders in autism is debated, but it is clear that they complicate support provision and clinical management, and can have negative impact on outcomes. This systematic review and meta-analysis explored the full range of co-occurring neurological disorders in autism. We estimated the odds of having neurological complications compared to the general population and other neurodevelopmental conditions, as well as the overall prevalence of different neurological disorders. Seventy-nine articles were eligible for the systematic review, including 28 case-control studies, 43 prevalence studies, and 8 cohort studies. Findings were heterogeneous across studies. Overall, autistic individuals were significantly more likely than the general population to exhibit epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headache, and congenital abnormalities of the nervous system, with prevalence estimates ranging from 1.1% (0%-3.3%; hydrocephalus) to 14.2% (11.3%-17.2%; epilepsy). Epilepsy was also more common in autism than in attention-deficit/hyperactivity disorder (odds ratio [95% confidence interval] = 4.06 [2.81-5.88]). Findings indicate that awareness of neurological disorders and neurological check-ups are indicated in autism to ensure adequate physical health care and support. Prospective studies of neurological disorders in children diagnosed with or at risk of autism might further enhance our understanding of causal pathways. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2022/1/01