Striatal Dopamine D1 Receptors Control Motivation to Respond, but Not Interval Timing, during the Timing Task

Autor/inn/en	Kamada, Taisuke; Hata, Toshimichi
Titel	Striatal Dopamine D1 Receptors Control Motivation to Respond, but Not Interval Timing, during the Timing Task
Quelle	In: Learning & Memory, 28 (2021) 1, S.24-29 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.052266.120
Schlagwörter	Neurology; Physiology; Time; Perception; Intervals; Animals; Intervention; Reaction Time; Motivation; Responses + Suchen Sie Ihr Suchwort? Neurologie; Physiologie; Zeit; Wahrnehmung; Animal; Tier; Tiere; Reaktionsvermögen; psychologische; Motivation (psychologisch)
Abstract	Dopamine plays a critical role in behavioral tasks requiring interval timing (time perception in a seconds-to-minutes range). Although some studies demonstrate the role of dopamine receptors as a controller of the speed of the internal clock, other studies demonstrate their role as a controller of motivation. Both D1 dopamine receptors (D1DRs) and D2 dopamine receptors (D2DRs) within the dorsal striatum may play a role in interval timing because the dorsal striatum contains rich D1DRs and D2DRs. However, relative to D2DRs, the precise role of D1DRs within the dorsal striatum in interval timing is unclear. To address this issue, rats were trained on the peak-interval 20-sec procedure, and D1DR antagonist SCH23390 was infused into the bilateral dorsocentral striatum before behavioral sessions. Our results showed that the D1DR blockade drastically reduced the maximum response rate and increased the time to start responses with no effects on the time to terminate responses. These findings suggest that the D1DRs within the dorsal striatum are required for motivation to respond, but not for modulation of the internal clock speed. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01