Bidirectional Regulation of Distinct Memory Domains by [alpha]5-Subunit-Containing GABA[subscript A] Receptors in CA1 Pyramidal Neurons

Autor/inn/en	Engin, Elif; Sigal, Maksim; Benke, Dietmar; Zeller, Anja; Rudolph, Uwe
Titel	Bidirectional Regulation of Distinct Memory Domains by [alpha]5-Subunit-Containing GABA[subscript A] Receptors in CA1 Pyramidal Neurons
Quelle	In: Learning & Memory, 27 (2020) 10, S.423-428 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Brain Hemisphere Functions; Memory; Animals; Spatial Ability; Fear; Conditioning; Cytology; Inhibition; Comparative Analysis + Suchen Sie Ihr Suchwort? Gedächtnis; Animal; Tier; Tiere; Räumliches Vorstellungsvermögen; Furcht; Zytologie; Hemmung
Abstract	Reduction in the expression or function of [alpha]5-subunit-containing GABA[subscript A] receptors ([alpha]5GABA[subscript A]Rs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of [alpha]5GABA[subscript A]Rs in CA1 pyramidal neurons ([alpha]5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, [alpha]5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impairment in context discrimination, suggesting fine-tuning of activity in CA1 pyramidal cell dendrites through [alpha]5-mediated inhibition might be necessary for distinguishing highly similar contexts. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01