An Acute Seizure Prior to Memory Reactivation Transiently Impairs Associative Memory Performance in C57BL/6J Mice

Autor/inn/en	Binder, Matthew S.; Kim, Andrew D.; Lugo, Joaquin N.
Titel	An Acute Seizure Prior to Memory Reactivation Transiently Impairs Associative Memory Performance in C57BL/6J Mice
Quelle	In: Learning & Memory, 27 (2020) 9, S.340-345 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.050633.119
Schlagwörter	Seizures; Memory; Neurological Impairments; Epilepsy; Comorbidity; Animals; Conditioning; Associative Learning; Cognitive Processes + Suchen Sie Ihr Suchwort? Anfallsleiden; Gedächtnis; Neurodegenerative Erkrankung; Epilepsie; Animal; Tier; Tiere; Cognitive process; Kognitiver Prozess
Abstract	Memory deficits significantly decrease an individual's quality of life and are a pervasive comorbidity of epilepsy. Despite the various distinct processes of memory, the majority of epilepsy research has focused on seizures during the encoding phase of memory, therefore the effects of a seizure on other memory processes is relatively unknown. In the present study, we investigated how a single seizure affects memory reactivation in C57BL/6J adult mice using an associative conditioning paradigm. Initially, mice were trained to associate a tone (conditioned stimulus), with the presence of a shock (unconditioned stimulus). Flurothyl was then administered 1 h before, 1 h after, or 6 h before a memory reactivation trial. The learned association was then assessed by presenting a conditioned stimulus in a new context 24 h or 1 wk after memory reactivation. We found that mice receiving a seizure 1 h prior to reactivation exhibited a deficit in memory 24 h later but not 1 wk later. When mice were administered a seizure 6 h before or 1 h after reactivation, there were no differences in memory between seizure and control animals. Altogether, our study indicates that an acute seizure during memory reactivation leads to a temporary deficit in associative memory in adult mice. These findings suggest that the cognitive impact of a seizure may depend on the timing of the seizure relative to the memory process that is active. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01