The Effects of Deep Brain Stimulation on Speech Intelligibility in Persons with Essential Tremor

Autor/inn/en	Sandström, Linda; Blomstedt, Patric; Karlsson, Fredrik; Hartelius, Lena
Titel	The Effects of Deep Brain Stimulation on Speech Intelligibility in Persons with Essential Tremor
Quelle	In: Journal of Speech, Language, and Hearing Research, 63 (2020) 2, S.456-471 (16 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Stimulation; Brain Hemisphere Functions; Neurological Impairments; Symptoms (Individual Disorders); Sentences; Language Tests; Swedish; Patients; Comparative Analysis; Speech Communication; Outcomes of Treatment; Articulation (Speech); Age Differences; Diagnostic Tests; Foreign Countries; Listening Comprehension; Self Evaluation (Individuals); Speech Impairments; Auditory Perception; Correlation; Sweden + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Psychiatrische Symptomatik; Sentence analysis; Satzanalyse; Language test; Sprachtest; Schwedisch; Patient; Age; Difference; Age difference; Altersunterschied; Diagnostic test; Diagnostischer Test; Ausland; Hörverständnis; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung; Auditive Wahrnehmung; Akustische Wahrnehmung; Akustik; Korrelation; Schweden
Abstract	Purpose: The aim of this study was to investigate how deep brain stimulation (DBS) of the caudal zona incerta (cZi) affects speech intelligibility in persons with essential tremor. Method: Thirty-five participants were evaluated: off stimulation, on chronic stimulation optimized to alleviate tremor, and during unilateral stimulation at increasing amplitude levels. At each stimulation condition, the participants read 10 unique nonsense sentences from the Swedish Test of Intelligibility. Two listeners, blinded to stimulation condition, transcribed all recorded sentences orthographically in a randomized procedure. A mean speech intelligibility score for each patient and stimulation condition was computed, and comparisons were made between scores off and on stimulation. Results: Chronic cZi-DBS had no significant effect on speech intelligibility, and there was no difference in outcome between bilateral and unilateral treatments. During unilateral stimulation at increasing amplitudes, nine participants demonstrated deteriorating speech intelligibility. These nine participants were on average older and had more superior contacts activated during the evaluation compared with the participants without deterioration. Conclusions: Chronic cZi-DBS, optimized for tremor suppression, does not generally affect speech intelligibility in persons with essential tremor. Furthermore, speech intelligibility may be preserved in many individuals, even when stimulated at high amplitudes. Adverse effects of high-amplitude unilateral stimulation observed in this study were associated with stimulation originating from a more superior location, as well as with the participants' age. These results, highlighting age and stimulation location as contributing to speech intelligibility outcomes, were, however, based on a limited number of individuals experiencing adverse effects with high-amplitude stimulation and should, therefore, be interpreted with caution. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2022/1/01