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Autor/inn/enFujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko
TitelDepotentiation Depends on IP[subscript 3] Receptor Activation Sustained by Synaptic Inputs after LTP Induction
QuelleIn: Learning & Memory, 27 (2020) 2, S.52-66 (15 Seiten)
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Spracheenglisch
Dokumenttypgedruckt; online; Zeitschriftenaufsatz
ISSN1072-0502
DOI10.1101/lm.050344.119
SchlagwörterBrain; Animals; Brain Hemisphere Functions; Stimuli; Inhibition; Metabolism; Neurological Organization
AbstractIn CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (LFS, 1000 pulses at 2 Hz) at 30 min after HFS (depotentiation), and this effect was inhibited when test synaptic stimulation was halted for a 19-min period after HFS or for a 20-min period after LFS or applied over the same time period in the presence of an antagonist of N-methyl-D-aspartate receptors (NMDARs), group I metabotropic glutamate receptors (mGluRs), or inositol 1, 4, 5-trisphosphate receptors (IP[subscript 3]Rs). Depotentiation was also blocked by the application of a Ca[superscript 2+]/calmodulin-dependent protein kinase II (CaMKII) inhibitor or a calcineurin inhibitor applied in the presence of test synaptic input for a 10-min period after HFS or for a 20-min period after LFS. These results suggest that, in postsynaptic neurons, the coactivation of NMDARs and group I mGluRs due to sustained synaptic activity following LTP induction results in the activation of IP[subscript 3]Rs and CaMKII, which leads to the activation of calcineurin after LFS and depotentiation of CA1 synaptic responses. (As Provided).
AnmerkungenCold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst vonERIC (Education Resources Information Center), Washington, DC
Update2022/1/01
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