CREB Transcription in the Medial Prefrontal Cortex Regulates the Formation of Long-Term Associative Recognition Memory

Autor/inn/en	Barker, Gareth Robert; Wong, Liang Fong; Uney, James B.; Warburton, Elizabeth C.
Titel	CREB Transcription in the Medial Prefrontal Cortex Regulates the Formation of Long-Term Associative Recognition Memory
Quelle	In: Learning & Memory, 27 (2020) 2, S.45-51 (7 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Warburton, Elizabeth C.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.050021.119
Schlagwörter	Brain Hemisphere Functions; Long Term Memory; Recognition (Psychology); Spatial Ability; Neurological Impairments; Animals + Suchen Sie Ihr Suchwort? Langzeitgedächtnis; Recognition; Wiedererkennen; Räumliches Vorstellungsvermögen; Neurodegenerative Erkrankung; Animal; Tier; Tiere
Abstract	The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2022/1/01