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Autor/inn/enOruro, Enver Miguel; Pardo, Grace V. E.; Lucion, Aldo B.; Calcagnotto, Maria Elisa; Idiart, Marco A. P.
TitelMaturation of Pyramidal Cells in Anterior Piriform Cortex May Be Sufficient to Explain the End of Early Olfactory Learning in Rats
QuelleIn: Learning & Memory, 27 (2020) 1, S.20-32 (13 Seiten)
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ZusatzinformationORCID (Pardo, Grace V. E.)
ORCID (Lucion, Aldo B.)
ORCID (Calcagnotto, Maria Elisa)
ORCID (Idiart, Marco A. P.)
Spracheenglisch
Dokumenttypgedruckt; online; Zeitschriftenaufsatz
ISSN1072-0502
DOI10.1101/lm.050724.119
SchlagwörterAnimal Behavior; Cytology; Learning Processes; Preferences; Olfactory Perception; Correlation; Tactual Perception; Conditioning; Computer Software; Brain Hemisphere Functions; Attachment Behavior; Diagnostic Tests; Genetics
AbstractStudies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermo-tactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups younger than 10 postnatal days (P), but not older, rapidly induce an orientation-approximation behavior toward the conditioned odor in a two-choice preference test. The olfactory bulb (OB) and the anterior olfactory cortex (aPC), both modulated by norepinephrine (NE), have been identified as part of a neural circuit supporting this transitory olfactory learning. One possible explanation at the neuronal level for why the odor-stroke pairing induces consistent orientation-approximation behavior in <P10 pups, but not in >P10, is the coincident activation of prior existent neurons in the aPC mediating this behavior. Specifically, odor-stroke conditioning in <P10 pups may activate more mother/nest odor's responsive aPC neurons than in >P10 pups, promoting orientation-approximation behavior in the former but not in the latter. In order to test this hypothesis, we performed in vitro patch-clamp recordings of the aPC pyramidal neurons from rat pups from two age groups (P5-P8 and P14-P17) and built computational models for the OB-aPC neural circuit based on this physiological data. We conditioned the P5-P8 OB-aPC artificial circuit to an odor associated with NE activation (representing the process of maternal odor learning during mother-infant interactions inside the nest) and then evaluated the response of the OB-aPC circuit to the presentation of the conditioned odor. The results show that the number of responsive aPC neurons to the presentation of the conditioned odor in the P14-P17 OB-aPC circuit was lower than in the P5-P8 circuit, suggesting that at P14-P17, the reduced number of responsive neurons to the conditioned (maternal) odor might not be coincident with the responsive neurons for a second conditioned odor. (As Provided).
AnmerkungenCold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst vonERIC (Education Resources Information Center), Washington, DC
Update2022/1/01
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