Behavioral and Immunohistochemical Characterization of Rapid Reconditioning Following Extinction of Contextual Fear

Autor/inn/en	Williams, Amy R.; Kim, Earnest S.; Lattal, K. Matthew
Titel	Behavioral and Immunohistochemical Characterization of Rapid Reconditioning Following Extinction of Contextual Fear
Quelle	In: Learning & Memory, 26 (2019) 10, S.387-402 (16 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.048439.118
Schlagwörter	Fear; Conditioning; Context Effect; Memory; Comparative Analysis; Learning Experience; Neurology; Biology; Behavior Patterns; Behavior Change; Brain Hemisphere Functions; Correlation; Biochemistry; Animals; Animal Behavior + Suchen Sie Ihr Suchwort? Furcht; Gedächtnis; Lernerfahrung; Neurologie; Biologie; Korrelation; Biochemie; Animal; Tier; Tiere; Tierverhalten
Abstract	A fundamental property of extinction is that the behavior that is suppressed during extinction can be unmasked through a number of postextinction procedures. Of the commonly studied unmasking procedures (spontaneous recovery, reinstatement, contextual renewal, and rapid reacquisition), rapid reacquisition is the only approach that allows a direct comparison between the impact of a conditioning trial before or after extinction. Thus, it provides an opportunity to evaluate the ways in which extinction changes a subsequent learning experience. In five experiments, we investigate the behavioral and neurobiological mechanisms of postextinction reconditioning. We show that rapid reconditioning of unsignaled contextual fear after extinction in male Long--Evans rats is associative and not affected by the number or duration of extinction sessions that we examined. We then evaluate c-Fos expression and histone acetylation (H4K8) in the hippocampus, amygdala, prefrontal cortex, and bed nucleus of the stria terminalis. We find that in general, initial conditioning has a stronger impact on c-Fos expression and acetylation than does reconditioning after extinction. We discuss implications of these results for theories of extinction and the neurobiology of conditioning and extinction. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01