A Novel Framework to Measure Executive Function in Down Syndrome with Applications for Early Clinical Diagnosis of Dementia

Autor/inn/en	Smith, Elizabeth; Hedge, Craig; Jarrold, Christopher
Titel	A Novel Framework to Measure Executive Function in Down Syndrome with Applications for Early Clinical Diagnosis of Dementia
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 124 (2019) 4, S.354-373 (20 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
Schlagwörter	Executive Function; Down Syndrome; Identification; Clinical Diagnosis; Memory; Reaction Time; Dementia; Accuracy; Adults; Alzheimers Disease + Suchen Sie Ihr Suchwort? 'Downs Syndrome; Down''s Syndrome'; Down-Syndrom; Identifikation; Identifizierung; Gedächtnis; Reaktionsvermögen; Demenz
Abstract	Executive function (EF) decline is a consistent early sign of Alzheimer's disease (AD) among adults with Down syndrome (DS), which means that baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory, and temporal components) within one task. Increases in memory load, inhibitory load, and temporal demands led to significant increases in reaction times and significant decreases in accuracy among 18 adults with DS and 18 typically developing matched individuals; thus, the expected effects of all three manipulations were detected. Good test-retest reliability indicated that this framework has the potential to provide a simple, baseline EF measure for individuals with DS. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aaiddjournals.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01