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Autor/inn/enAbbeduto, Leonard; Thurman, Angela John; McDuffie, Andrea; Klusek, Jessica; Feigles, Robyn Tempero; Ted Brown, W.; Harvey, Danielle J.; Adayev, Tatyana; LaFauci, Giuseppe; Dobkins, Carl; Roberts, Jane E.
TitelASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males
QuelleIn: Journal of Autism and Developmental Disorders, 49 (2019) 3, S.960-977 (18 Seiten)
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Spracheenglisch
Dokumenttypgedruckt; online; Zeitschriftenaufsatz
ISSN0162-3257
DOI10.1007/s10803-018-3796-2
SchlagwörterMales; Genetic Disorders; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders); Adolescents; Young Adults; Severity (of Disability); Language Impairments; Cognitive Ability; Behavior Problems; Interpersonal Competence; Affective Behavior; Predictor Variables; Expressive Language; Syntax; Comorbidity
AbstractMany males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed. (As Provided).
AnmerkungenSpringer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Erfasst vonERIC (Education Resources Information Center), Washington, DC
Update2020/1/01
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