Associations between Parental Broader Autism Phenotype and Child Autism Spectrum Disorder Phenotype in the Study to Explore Early Development

Autor/inn/en	Rubenstein, Eric; Wiggins, Lisa D.; Schieve, Laura A.; Bradley, Chyrise; DiGuiseppi, Carolyn; Moody, Eric; Pandey, Juhi; Pretzel, Rebecca Edmondson; Howard, Annie Green; Olshan, Andrew F.; Pence, Brian W.; Daniels, Julie
Titel	Associations between Parental Broader Autism Phenotype and Child Autism Spectrum Disorder Phenotype in the Study to Explore Early Development
Quelle	In: Autism: The International Journal of Research and Practice, 23 (2019) 2, S.436-448 (13 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Rubenstein, Eric)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361317753563
Schlagwörter	Autism; Pervasive Developmental Disorders; Parents; Young Children; Symptoms (Individual Disorders); Genetics; Gender Differences; Developmental Delays; Motor Development; Child Behavior; Cognitive Ability; Language Acquisition; California; Colorado; Georgia; Maryland; North Carolina; Pennsylvania; Autism Diagnostic Observation Schedule; Child Behavior Checklist; Mullen Scales of Early Learning + Suchen Sie Ihr Suchwort? Autismus; Eltern; Frühe Kindheit; Psychiatrische Symptomatik; Humangenetik; Geschlechterkonflikt; Entwicklungsverzögerung; Motorische Entwicklung; Denkfähigkeit; Sprachaneignung; Spracherwerb; Kalifornien
Abstract	The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype--a set of sub-clinical characteristics of autism spectrum disorder--on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: "Mild Language Delay with Cognitive Rigidity," "Mild Language and Motor Delay with Dysregulation" (e.g. anxiety/depression), "General Developmental Delay," and "Significant Developmental Delay with Repetitive Motor Behaviors." Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01