A Complex mTOR Response in Habituation Paradigms for a Social Signal in Adult Songbirds

Autor/inn/en	Ahmadiantehrani, Somayeh; Gores, Elisa O.; London, Sarah E.
Titel	A Complex mTOR Response in Habituation Paradigms for a Social Signal in Adult Songbirds
Quelle	In: Learning & Memory, 25 (2018) 6, S.273-282 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.046417.117
Schlagwörter	Habituation; Associative Learning; Correlation; Singing; Animals; Animal Behavior; Molecular Structure; Recognition (Psychology); Cognitive Processes; Biochemistry; Familiarity; Statistical Analysis; Regression (Statistics); Illinois (Chicago) + Suchen Sie Ihr Suchwort? Korrelation; Gesang; Animal; Tier; Tiere; Tierverhalten; Recognition; Wiedererkennen; Cognitive process; Kognitiver Prozess; Biochemie; Statistische Analyse; Regression; Regressionsanalyse
Abstract	Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we examined song recognition learning in adult zebra finches. These colonial songbirds learn the unique song of individuals, which helps establish and maintain mate and other social bonds, and informs appropriate behavioral interactions with specific birds. We leveraged prior work demonstrating behavioral habituation for individual songs, and extended the molecular framework correlated with this behavior by investigating the mechanistic Target of Rapamycin (mTOR) signaling cascade. We hypothesized that mTOR may contribute to habituation because it integrates a variety of upstream signals and enhances associative learning, and it crosstalks with another cascade previously associated with habituation, ERK/ZENK. To begin probing for a possible role for mTOR in song recognition learning, we used a combination of song playback paradigms and bidirectional dysregulation of mTORC1 activation. We found that mTOR demonstrates the molecular signatures of a habituation mechanism, and that its manipulation reveals the complexity of processes that may be invoked during nonassociative learning. These results thus expand the molecular targets for habituation studies and raise new questions about neural processing of complex natural signals. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01