Drug Design Workshop: A Web-Based Educational Tool to Introduce Computer-Aided Drug Design to the General Public

Autor/inn/en	Daina, Antoine; Blatter, Marie-Claude; Gerritsen, Vivienne Baillie; Palagi, Patricia M.; Marek, Diana; Xenarios, Ioannis; Schwede, Torsten; Michielin, Olivier; Zoete, Vincent
Titel	Drug Design Workshop: A Web-Based Educational Tool to Introduce Computer-Aided Drug Design to the General Public
Quelle	In: Journal of Chemical Education, 94 (2017) 3, S.335-344 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Zoete, Vincent)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.6b00596
Schlagwörter	Science Instruction; Biochemistry; Cooperative Learning; Pharmacology; Molecular Structure; Science Process Skills; Drug Therapy; Medicine; Web Sites; Workshops; Design; High School Students; Student Attitudes; Program Effectiveness; Technology Uses in Education; Educational Technology; Foreign Countries; Switzerland + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Biochemie; Kooperatives Lernen; Arzneikunde; Medizin; Web-Design; Lernwerkstatt; Schulung; High school; High schools; Student; Students; Oberschule; Schüler; Schülerin; Studentin; Schülerverhalten; Technology enhanced learning; Technology aided learning; Technologieunterstütztes Lernen; Unterrichtsmedien; Ausland; Schweiz
Abstract	Due to its impact on society, the design of new drugs has the potential to interest a wide audience, and provides a rare opportunity to introduce several concepts in chemistry and biochemistry. Drug design can be seen as a multiobjective cyclic optimization process. Indeed, it is important to develop the understanding not only that a drug is generally an effective ligand for a protein of therapeutic interest, but also that these molecules need to have drug-like properties. Computer-aided drug design and bioinformatics approaches play a fundamental role in addressing these different challenges. Here we introduce a new freely available integrated web-based educational tool, Drug Design Workshop, which presents the basics of drug design and provides anyone with access to computational methods and resources to conceive and evaluate molecules for their potential to become actual drugs. We provide 3 examples of drug design targets for the discovery of common or state-of-the-art drugs, which can be used by educators to introduce easily the different concepts related to drug discovery: anti-inflammatory agents and drugs for immunotherapy or targeted cancer therapy. Since 2015, the workshop has been successfully given to over 1,500 people. The Web site was optimized on the basis of the positive and constructive comments from high-school teachers and students (15-19 years old). (As Provided).
Anmerkungen	Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01