Stimulant-Related Reductions of Growth Rates in the PATS

Autor/inn/en	Swanson, James; Greenhill, Laurence; Wigal, Tim; Kollins, Scott; Stehli, Annamarie; Davies, Mark; Chuang, Shirley; Vitiello, Benedetto; Skrobala, Anne; Posner, Kelly; Abikoff, Howard; Oatis, Melvin; McCracken, James; McGough, James; Riddle, Mark; Ghuman, Jaswinder; Cunningham, Charles; Wigal, Sharon
Titel	Stimulant-Related Reductions of Growth Rates in the PATS
Quelle	In: Journal of the American Academy of Child and Adolescent Psychiatry, 45 (2006) 11, S.1304-1313 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
Schlagwörter	Stimulants; Hyperactivity; Attention Deficit Disorders; Body Height; Body Weight; Preschool Children; Drug Therapy; Pharmacology; Outcomes of Treatment; Longitudinal Studies; At Risk Persons + Suchen Sie Ihr Suchwort? Droge; Hyperaktivität; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Körpergröße; Körpergewicht; Pre-school age; Preschool age; Child; Children; Pre-school education; Preschool education; Vorschulalter; Kind; Kinder; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Arzneikunde; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Risikogruppe
Abstract	Objective: To investigate growth of children with attention-deficit/hyperactivity disorder (ADHD) in the Preschool ADHD Treatment Study (PATS) before and after initiation of treatment with methylphenidate at titrated doses (average, 14.2 mg/day) administered three times daily, 7 days/week for approximately equal to 1 year. Method: The heights and weights of 140 children with ADHD were measured up to 29 times in the PATS protocol, starting at an average age of 4.4 years. The relationship between standard (z) scores and time on medication was examined using mixed-effect regression to estimate change in relative size (slope). Results: Average relative size at baseline was significantly (p less than 0.0001) greater than zero for z height (+0.45) and z weight (+0.78), indicating greater than expected height (by 2.04 cm) and weight (by 1.78 kg). During treatment, slopes were significantly (p less than 0.0001) less than zero for z height (-0.304/yr) and z weight (-0.530/yr), indicating reduction of growth rates. For 95 children who remained on medication, annual growth rates were 20.3% less than expected for height (5.41 cm/yr - 6.79 cm/yr = -1.38 cm/yr) and 55.2% for weight (1.07 kg/yr - 2.39 kg/yr = -1.32 kg/yr). Conclusions: Risks of reduced growth rates should be balanced against expected benefits when preschool-age children are treated with stimulant medication. (Contains 2 figures and 2 tables.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10