a[subscript 2]-Adrenergic Receptor Activation Promotes Long-Term Potentiation at Excitatory Synapses in the Mouse Accessory Olfactory Bulb

Autor/inn/en	Huang, Guang-Zhe; Taniguchi, Mutsuo; Zhou, Ye-Bo; Zhang, Jing-Ji; Okutani, Fumino; Murata, Yoshihiro; Yamaguchi, Masahiro; Kaba, Hideto
Titel	a[subscript 2]-Adrenergic Receptor Activation Promotes Long-Term Potentiation at Excitatory Synapses in the Mouse Accessory Olfactory Bulb
Quelle	In: Learning & Memory, 25 (2018) 4, S.147-157 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.046391.117
Schlagwörter	Brain Hemisphere Functions; Biochemistry; Stimulation; Olfactory Perception; Animals; Recognition (Psychology); Memory; Inhibition; Hypothesis Testing; Experiments; Statistical Analysis + Suchen Sie Ihr Suchwort? Biochemie; Animal; Tier; Tiere; Recognition; Wiedererkennen; Gedächtnis; Hemmung; Hypothesenprüfung; Hypothesentest; Erprobung; Statistische Analyse
Abstract	The formation of mate recognition memory in mice is associated with neural changes at the reciprocal dendrodendritic synapses between glutamatergic mitral cell (MC) projection neurons and GABAergic granule cell (GC) interneurons in the accessory olfactory bulb (AOB). Although noradrenaline (NA) plays a critical role in the formation of the memory, the mechanism by which it exerts this effect remains unclear. Here we used extracellular field potential and whole-cell patch-clamp recordings to assess the actions of bath-applied NA (10 µM) on the glutamatergic transmission and its plasticity at the MC-to-GC synapse in the AOB. Stimulation (400 stimuli) of MC axons at 10 Hz but not at 100 Hz effectively induced N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP), which exhibited reversibility. NA paired with subthreshold 10-Hz stimulation (200 stimuli) facilitated the induction of NMDA receptor-dependent LTP via the activation of a[subscript 2]-adrenergic receptors (ARs). We next examined how NA, acting at a[subscript 2]-ARs, facilitates LTP induction. In terms of acute actions, NA suppressed GC excitatory postsynaptic current (EPSC) responses to single pulse stimulation of MC axons by reducing glutamate release from MCs via G-protein coupled inhibition of calcium channels. Consequently, NA reduced recurrent inhibition of MCs, resulting in the enhancement of evoked EPSCs and spike fidelity in GCs during the 10-Hz stimulation used to induce LTP. These results suggest that NA, acting at a[subscript 2]-ARs, facilitates the induction of NMDA receptor-dependent LTP at the MC-to-GC synapse by shifting its threshold through disinhibition of MCs. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01